A lignan-derived phenol a GPR35 agonist (EC50 147 UM in a DMR assay) using HT-29 cells promotes esophageal carcinogenesis in rats at 2 in the diet either alone or in a multiorgan model of nitrosamine-induced carcinogenesis has been used as a precursor in the enzymatic synthesis of pyrogallol and purpurogallin has been used as a precursor in the electro-organic synthesis of coumestan derivatives